1,202 research outputs found
Coadministration of Anti-Viral Monoclonal Antibodies With Routine Pediatric Vaccines and Implications for Nirsevimab Use: A White Paper
Routine childhood vaccinations are key for the protection of children from a variety of serious and potentially fatal diseases. Current pediatric vaccine schedules mainly cover active vaccines. Active vaccination in infants is a highly effective approach against several infectious diseases; however, thus far, for some important viral pathogens, including respiratory syncytial virus (RSV), vaccine development and license by healthcare authorities have not been accomplished. Nirsevimab is a human-derived, highly potent monoclonal antibody (mAb) with an extended half-life for RSV prophylaxis in all infants. In this manuscript, we consider the potential implications for the introduction of an anti-viral mAb, such as nirsevimab, into the routine pediatric vaccine schedule, as well as considerations for coadministration. Specifically, we present evidence on the general mechanism of action of anti-viral mAbs and experience with palivizumab, the only approved mAb for the prevention of RSV infection in preterm infants, infants with chronic lung disease of prematurity and certain infants with hemodynamically significant heart disease. Palivizumab has been used for over two decades in infants who also receive routine vaccinations without any alerts concerning the safety and efficacy of coadministration. Immunization guidelines (Advisory Committee on Immunization Practices, Joint Committee on Vaccination and Immunization, National Advisory Committee on Immunization, Centers for Disease Control and Prevention, American Academy of Pediatrics, The Association of the Scientific Medical Societies in Germany) support coadministration of palivizumab with routine pediatric vaccines, noting that immunobiologics, such as palivizumab, do not interfere with the immune response to licensed live or inactivated active vaccines. Based on the mechanism of action of the new generation of anti-viral mAbs, such as nirsevimab, which is highly specific targeting viral antigenic sites, it is unlikely that it could interfere with the immune response to other vaccines. Taken together, we anticipate that nirsevimab could be concomitantly administered to infants with routine pediatric vaccines during the same clinic visit
Incremental QBF Solving
We consider the problem of incrementally solving a sequence of quantified
Boolean formulae (QBF). Incremental solving aims at using information learned
from one formula in the process of solving the next formulae in the sequence.
Based on a general overview of the problem and related challenges, we present
an approach to incremental QBF solving which is application-independent and
hence applicable to QBF encodings of arbitrary problems. We implemented this
approach in our incremental search-based QBF solver DepQBF and report on
implementation details. Experimental results illustrate the potential benefits
of incremental solving in QBF-based workflows.Comment: revision (camera-ready, to appear in the proceedings of CP 2014,
LNCS, Springer
Science Requirements and Conceptual Design for a Polarized Medium Energy Electron-Ion Collider at Jefferson Lab
This report presents a brief summary of the science opportunities and program
of a polarized medium energy electron-ion collider at Jefferson Lab and a
comprehensive description of the conceptual design of such a collider based on
the CEBAF electron accelerator facility.Comment: 160 pages, ~93 figures This work was supported by the U.S. Department
of Energy, Office of Nuclear Physics, under Contract No. DE-AC05-06OR23177,
DE-AC02-06CH11357, DE-AC05-060R23177, and DESC0005823. The U.S. Government
retains a non-exclusive, paid-up, irrevocable, world-wide license to publish
or reproduce this manuscript for U.S. Government purpose
Nucleon-induced reactions at intermediate energies: New data at 96 MeV and theoretical status
Double-differential cross sections for light charged particle production (up
to A=4) were measured in 96 MeV neutron-induced reactions, at TSL laboratory
cyclotron in Uppsala (Sweden). Measurements for three targets, Fe, Pb, and U,
were performed using two independent devices, SCANDAL and MEDLEY. The data were
recorded with low energy thresholds and for a wide angular range (20-160
degrees). The normalization procedure used to extract the cross sections is
based on the np elastic scattering reaction that we measured and for which we
present experimental results. A good control of the systematic uncertainties
affecting the results is achieved. Calculations using the exciton model are
reported. Two different theoretical approches proposed to improve its
predictive power regarding the complex particle emission are tested. The
capabilities of each approach is illustrated by comparison with the 96 MeV data
that we measured, and with other experimental results available in the
literature.Comment: 21 pages, 28 figure
Progress on the Interaction Region Design and Detector Integration at Jlab\u27s MEIC
One of the unique features of JLab\u27s Medium-energy Electron-Ion Collider (MEIC) is a full-acceptance detector with a dedicated, small-angle, high-resolution detection system, capable of covering a wide range of momenta (and charge-to-mass ratios) with respect to the original ion beam to enable access to new physics. We present an interaction region design developed with close integration of the detection and beam dynamical aspects. The dynamical aspect of the design rests on a symmetry-based concept for compensation of non-linear effects. The optics and geometry have been optimized to accommodate the detection requirements and to ensure the interaction region\u27s modularity for ease of integration into the collider ring lattices. As a result, the design offers an excellent detector performance combined with the necessary provisions for non-linear dynamical optimization
Reinventing grounded theory: some questions about theory, ground and discovery
Grounded theoryâs popularity persists after three decades of broad-ranging critique. In this article three problematic notions are discussedââtheory,â âgroundâ and âdiscoveryââwhich linger in the continuing use and development of grounded theory procedures. It is argued that far from providing the epistemic security promised by grounded theory, these notionsâembodied in continuing reinventions of grounded theoryâconstrain and distort qualitative inquiry, and that what is contrived is not in fact theory in any meaningful sense, that âgroundâ is a misnomer when talking about interpretation and that what ultimately materializes following grounded theory procedures is less like discovery and more akin to invention. The procedures admittedly provide signposts for qualitative inquirers, but educational researchers should be wary, for the significance of interpretation, narrative and reflection can be undermined in the procedures of grounded theory
Near-threshold Photoproduction of Phi Mesons from Deuterium
We report the first measurement of the differential cross section on
-meson photoproduction from deuterium near the production threshold for a
proton using the CLAS detector and a tagged-photon beam in Hall B at Jefferson
Lab. The measurement was carried out by a triple coincidence detection of a
proton, and near the theoretical production threshold of 1.57 GeV.
The extracted differential cross sections for the initial
photon energy from 1.65-1.75 GeV are consistent with predictions based on a
quasifree mechanism. This experiment establishes a baseline for a future
experimental search for an exotic -N bound state from heavier nuclear
targets utilizing subthreshold/near-threshold production of mesons
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